Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains.

Two-component systems (TCSs) are important for the adaptation and survival of bacteria and fungi under stress conditions.A TCS is often composed of a membrane-bound sensor histidine kinase (SK) and a response regulator (RR), which are relayed Accessories through sequential phosphorylation steps.However, the mechanism for how an SK is switched on in

read more

Disease-Induced Cooperation Mitigates Populations Against Decline: The Cascade Effect of Cooperation Evolution

Due to density-dependent selection, the ecological factors impacting population dynamics can play an important role in promoting cooperation, and accordingly, benefit a population from the eco-evolutionary feedback.This implies that cooperation between individuals could help resist the attack of infectious diseases.Yet, little is known about how co

read more